Anthony Roberts has been researching anabolic steroids for over a decade and is the author of the new book, Anabolic Steroids: Ultimate Research Guide . He began his research at the age of seventeen while he was a competitive martial artist, ultimately winning a silver medal in his state martial arts tournament in the black belt division.
His firsthand experience in steroids began after he switched sports and began playing rugby, in which he ultimately made two consecutive appearances at the hooker position in the national collegiate all-star games. Along the way to his two national appearances, he won Player of the Year at his university and started every single game for all four years, spending every year since the end of the first as the team captain.
The logic for this myth actually makes a lot of sense – receptor down-regulation is pretty obvious when you drink a cup of coffee every day for a month, then find you need to keep increasing the size to get the same “kick”. We see (and feel) this receptor downgrade with caffeine, clenbuterol, ephedrine and a ton of other stuff, so it’s logical to think that we’re seeing the same thing with steroids. Sadly, the science tells us otherwise. Steroids actually do the opposite – they up-regulate your androgen receptors. It’s wrong to think about androgen receptors as permanent receptacles for the androgen ligand (sort of like a fixed electrical outlet in your house). In reality, your androgen receptors are constantly being turned over. When unattached to an androgen they have a half life of approximately three hours and are ultimately replaced with new ones. However, in the presence of an androgen (i.e. when they’re attached), they become more sensitive, their half life is doubled and the amount of new receptors being formed also increases substantially. It’s also important to remember that AR-mediated effects are not the whole story when it comes to anabolic steroid activity in the body. There are still a host of other effects that have little to nothing at all to do with AR, known as non-AR dependent effects, which include central nervous system stimulation and a host of other anabolic and potentially anabolic activities. But that still leaves us with the question of why our gains seem to slow down after a few cycles, and why we need to keep upping the dose. In truth, the answer probably has more to do with the body attempting to return to homeostasis through other mechanisms than it has with the androgen receptor per se. Still, if you’re worried about your androgen receptors you can take some L-Carnitine L-Tartrate, a nutritional supplement that has been shown to increase androgen receptors (it was included in Anavite, from Gaspari Nutrition, for this exact reason).
Anthony Roberts has been researching anabolic steroids for over a decade and is the author of “ Anabolic Steroids: Ultimate Research Guide,” addition to the ebook “ Beyond Steroids,” and is the co-author of the book “ Jekyll to Hyde: Physique Transformation from Both sides of the Force.” His latest book, Generation S, is in the final stages of publishing and will be released shortly by ECW Press.